Characterisation provided
We stand by the quality of our products.
We measure our enzymatic activities using validated methods. Each order of our 10 and 20-donor CryostaX is accompanied by a lot-specific data sheet.
We calculate theoretical enzymatic activities from the characterization of individual donors, and achieve those activities in the finished pooled product. All CYPs are targeted for average activity levels (based on our human hepatocyte characterization database) to assure lot-to-lot consistency.
Enzymatic activities
-
% viability
- CYP1A2 Phenacetin O-dealkylation
- CYP2A6 Coumarin 7-hydroxylation
- CYP2B6 Bupropion hydroxylation
- CYP2C8 Amodiaquine N-dealkylation
- CYP2C9 Diclofenac 4´-hydroxylation
- CYP2C19 S-Mephenytoin 4´-hydroxylation
- CYP2D6 Dextromethorphan O-demethylation
- CYP2E1 Chlorzoxazone 6-hydroxylation
- CYP3A4/5 Testosterone 6β-hydroxylation
- CYP3A4 Midazolam 1´-hydroxylation
- UGT 7-Hydroxycoumarin glucuronidation
- SULT 7-Hydroxycoumarin sulfonation
Donor information
- Age
- Ethnicity
- Gender
- Cause of death
- Infectious disease status
Please refer to Pool of 10 and Pool of 20 pages for respective specifications.
