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CryostaX - Single Freeze Pooled Cryopreserved Human Hepatocytes (pool of 10)
Cat nr HPCH10

Donor Information

Yield & Viability

(Yield and viability are based on experiments performed at XenoTech using XenoTech’s thawing protocol and K2000 Hepatocyte Isolation Kit.)

Enzymatic activities

Enzyme Marker substrate reaction pmol/million cells/min
CYP1A2 Phenacetin O-dealkylation 53.1 ± 3.6
CYP2A6 Coumarin 7-hydroxylation 18.1 ± 1.3
CYP2B6 Bupropion hydroxylation 68.5 ± 7.5
CYP2C8 Amodiaquine N-dealkylation 315 ± 25
CYP2C9 Diclofenac 4'-hydroxylation 325 ± 23
CYP2C19 S-Mephenytoin 4'-hydroxylation 4.9 ± 0.1
CYP2D6 Dextromethorphan O-demethylation 55.2 ± 1.5
CYP2E1 Chlorzoxazone 6-hydroxylation 278 ± 11
CYP3A4/5 Testosterone 6b-hydroxylation 213 ± 7
CYP3A4/5 Midazolam 1'-hydroxylation 48.5 ± 2.2
UGT 7 Hydroxycoumarin glucuronidation 734 ± 31
SULT 7 Hydroxycoumarin sulfonation 88.2 ± 5.9